Protein Lounge Peptide-Antigen Database

Category Cross-Omics>Knowledge Bases/Databases/Tools

Abstract The Peptide-Antigen Database contains antigenic peptide targets against all known protein sequences throughout a variety of organisms.

The database has also been subdivided into folders for peptide regions for Kinases, Phosphatases, Transcription Factors and Disease genes.

All peptide targets are linked to Protein Lounge's proprietary online hyrdoplotting tool - (see G6G Abstract Number 20195R), which allows you to view an interactive version of the protein sequence on a hydrophilicity/phobicity plot.

All proteins in the Peptide-Antigen database are also linked to Protein Lounge's Protein Database (available at the manufacturer’s home page) and Protein Lounge’s Pathway Database (available at the manufacturer’s home page), giving you detailed information about the genes which the peptides relate to.

Note: One of the most important aspects in the production of antibodies or drugs is the design of the peptide-antigen. The peptide-antigen is a small segment (15-18 amino acids) of the protein sequence of interest.

These peptide-antigens can be used for immunization in order to produce antibodies against the protein for which the peptide is from or the peptides can be used as a basis for small-molecule/drug targeting.

Parameters --

The parameters of the Peptide-Antigen Database are based on the methods for ‘peptide selection’ developed by Dr. Philip Goulder (Oxford), Dr. Otto Yang (UCLA) and Dr. Andrew Bradbury (LANL).

BEST TARGET: The ‘Best Target’ is the peptide which is the most hydrophilic, thus it is the region of the protein which has the best chance of surface exposure.

Validation Method --

The Peptide-Antigen targets which are listed in the Protein Lounge Peptide-Antigen database have been statistically validated, which means that the Protein Lounge has tested many of targets which have been generated in the Protein Lounge’s database through experimental methods to see if these targets induced antibody response.

Additional features/capabilities include:

1) Disease Gene Peptides -- Disease list is linked to the proteins which cause them and the peptide for those proteins.

2) Transcription Factors Peptides -- Transcription Factors are arranged by binding sites, tissue specificity and peptide targets.

3) Kinases/Phosphatases Peptides -- Complete list of Kinases/Phosphatases and their peptide targets.

Organisms include --

1) Homo sapiens - 24,225 Genes with 119,846 Peptide Sequences.

2) Mus musculus - 39,995 Genes with 212,168 Peptide Sequences.

3) Rattus norvegicus - 19,245 Genes with 95,044 Peptide Sequences.

4) Bos taurus - 1,169 Genes with 5,809 Peptide Sequences.

5) Danio rerio - 1,139 Genes with 5,651 Peptide Sequences.

6) Drosophila melanogaster - 17,673 Genes with 87,744 Peptide Sequences.

7) Anopheles gambiae - 15,297 Genes with 75,342 Peptide Sequences.

8) Caenorhabditis elegans - 26,843 Genes with 216,976 Peptide Sequences.

9) Arabidopsis thaliana - 15,276 Genes with 75,626 Peptide Sequences.

10) Saccharomyces cerevisiae - 5,655 Genes with 28,138 Peptide Sequences.

System Requirements

Contact manufacturer.

Manufacturer

Manufacturer Web Site Protein Lounge Peptide-Antigen Database and Protein Lounge Home

Price Contact manufacturer.

G6G Abstract Number 20194R

G6G Manufacturer Number 102215